Among the many 58 training included in the descriptive analysis, 41 had been situation accounts, one to are an incident collection, 13 had been retrospective cohort studies, one or two was prospective cohort education, and something is actually a mix-sectional cohort data. The feminine NF1 customers having cancer of the breast came from 23 additional countries, to the most of her or him originating from the united states of The usa (38%), British (31%), and Japan (12%). Characteristics of them cases was demonstrated in the Dining table step one.
Breast cancer stage at time of diagnosis was reported in 54 cases (27 cases of patients < 50 years of age and 27 cases of patients ?50 years of age)
Of the 286 cases identified, 181 reported the age of the patient. Mean age at breast cancer diagnosis was 49.3 years with a median age of 46 years and an interquartile range of 38.3 to 58.0 years. The majority of the patients were < 50 years of age with 53% < 50 years old, 28% between 35 and 44 years old and 15% < 35 years old. Age distribution of the incidence of breast cancer identified in these NF1 cases was evaluated based on their age at the time of diagnosis and revealed a peak age of diagnosis between the ages of 34 to 44 years. 2a).
Descriptive study out-of breast cancer circumstances claimed. a beneficial Many years shipping of the incidence regarding breast cancer recognized when you look at the 181 NF1 patients versus SEER database reported breast cancer decades distribution of event instances. b Distribution regarding breast cancer stage at the lifetime of medical diagnosis out of breast cancer known from inside the 54 NF1 people. c Ages distribution of one’s frequency from breast cancer demise understood when you look at the 76 NF1 people than the SEER database stated nipple malignant tumors years shipping out-of fatalities
This chance from breast cancer times was compared to SEER database to possess claimed cancer of the breast age shipping out of experience circumstances, and therefore demonstrated a maximum chronilogical age of analysis within period of 55 so you can 64 many years on standard populace (Fig
The type of breast cancer was reported in 110 cases; invasive ductal carcinoma (IDC) was the most commonly reported breast cancer subtype (75.5%). The other 176 breast cancer cases were identified as breast carcinoma. When analyzing all the female NF1 patients with breast cancer, the majority presented with stage I or II disease. However, when separated by age, women < 50 years of age presented with more advanced disease compared to those ?50 years of age (56% vs. 22% stage III-IV, respectively, p = 0.005; Fig. 2b).
Follow-up information was provided in 76 of the reported cases. Mean follow-up time was 44.7 months with a range of 1.9 to 204 months. Nearly half of the reported patients were dead at the time of last follow-up. Mean age at breast cancer death was 45.7 years with a median age of 48.5 years and an interquartile range of 41.3–59.7 years. The majority of the patients were < 50 years of age at time of breast cancer death with 64% < 50 years old, 38% between 35 and 44 years old and 10% < 35 years old. This incidence of breast cancer deaths was compared to the SEER database for reported breast cancer age distribution of deaths, demonstrating a peak age of death between the ages of 55 to 64 years in the general population (Fig. 2c). The relative survival of the female NF1 patients with breast cancer identified in this study was compared to the general population using the SEER database controlling for age and year at diagnosis for each patient (Fig. 3). The median survival for this entire NF1 breast cancer cohort was 5 years compared to the reported median breast cancer survival of over 20 years in the general population using the SEER database. When separated by age, the median survival of the female NF1 patients with breast cancer identified in this study was 5.58 years in those < 50 years of age and over 15 years in those ?50 years of age.